Pyridine, ACS, 99.0+%
化学性质
品级规格
应用
As polar, basic, low-reactive solvent, precursor, and reagent, pyridine finds wide range of applications in pharmaceuticals, agrochemicals and in the manufacture of dyes and rubber.Further it isused in the textile industry to improve network capacity of cotton.Pyridine finds applications in specialty chemical reagents like Cornforth reagent (pyridinium dichromate, PDC), pyridinium chlorochromate (PCC), the Collins reagent (complex of chromium(VI) oxide with pyridine) and the Sarret reagent (complex of chromium(VI) oxide with pyridine).Pyridine is a widely used ligand in coordination chemistry.Pyridine-base adducts like pyridine-borane (C5H5NBH3) and pyridine-sulfur trioxide (C5H5NSO3) are widely used owing to their superior characteristics in their reactivity and solubility characteristics.
注释
参考文献
Baumann, M.; Baxendale I. R.An overview of the synthetic routes to the best selling drugs containing 6-membered heterocycles.Beilstein J. Org. Chem. 2013, 9, 2265-2319.
Bull, J. A.; Mousseau, J. J.; Pelletier, G.; Charette, A. B.Synthesis of pyridine and dihydropyridine derivatives by regio- and stereoselective addition to N-activated pyridines. Chem. Rev. 2012, 112 (5), 2642-2713.
Widely used as a base and nucleophilic catalyst in acylations, sulfonylations, etc. See also 4-(Dimethylamino)pyridine, A13016.
Reacts with thionyl chloride to give N-(4-pyridyl)pyridinium chloride hydrochloride, a useful intermediate for the preparation of 4-substituted pyridines by nucleophilic displacement. Thus, reaction with sulfite ion gives the sulfonate: Org. Synth. Coll., 5, 977 (1973). Similarly, pyridine can be activated to substitution at the 4-position by reaction with Ethyl chloroformate, L06311, or tert-Butyldimethylsilyl trifluoromethanesulfonate, A12174. The acyl or silyl pyridinium salt then reacts with Grignards or organocuprates, to give 4-substituted dihydropyridines which can readily be rearomatized: Bull. Chem. Soc. Jpn., 57, 1994 (1984).
For use in Cr(VI) oxidation reactions, see Chromium(VI) oxide, 12522.
GHS危险和防护声明
危险说明（欧盟）:H225-H302+H312+H332-H315-H319
Highly flammable liquid and vapour. Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled. Causes skin irritation. Causes serious eye irritation.
防范说明:P233-P241-P242-P261-P264b-P270-P271-P280-P304+P340-P305+P351+P338-P312-P330-P363-P370+P378r-P403+P235-P501c
Keep container tightly closed. Use explosion-proof electrical/ventilating/lighting/ equipment. Use only non-sparking tools. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. Rinse mouth. Wash contaminated clothing before reuse. In case of fire: Store in a well-ventilated place. Keep cool. Dispose of contents/ container to an approved waste disposal plant
其他参考资料
文件
产品 SDS
质量分析报告(COA)
产品说明书
