2",3"-Dideoxycytidine, 98+%
化学性质
应用
2",3"-Dideoxycytidine in cells, it is phosphorylated to the active triphosphate form, ddCTP, which acts as a substrate for HIV reverse transcriptase (Ki = 51 nM). It incorporates into viral DNA where it terminates chain elongation when the missing hydroxyl group is encountered. It is also is used as a DNA chain-terminating nucleotide for DNA sequencing methods based on the Sanger chain-termination method.
注释
参考文献
E.Ullyatt; B.C.Liang. 2",3"-Dideoxycytidine is a potent inducer of apoptosis in glioblastoma cells. Anticancer Research. 1998, 18, (3A),1859-1863
C.H.Chen; Y.C.Cheng. Delayed cytotoxicity and selective loss of mitochondrial DNA in cells treated with the anti-human immunodeficiency virus compound 2",3"-dideoxycytidine. The Journal of Biological Chemistry. 1989, 264, (20),11934-11937
GHS危险和防护声明
危险说明（欧盟）:H351b
Suspected of causing cancer if inhaled
防范说明:P201-P202-P281-P308+P313-P403-P501c
Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Use personal protective equipment as required. IF exposed or concerned: Get medical advice/attention. Store in a well-ventilated place. Dispose of contents/ container to an approved waste disposal plant
其他参考资料
文件
产品 SDS
质量分析报告(COA)
产品说明书
